报告题目：SENP3 Sensitises Cells to lschaemia Insults via deSUMOylation of Drp1

报告人：郭堾（University of Britol）

报告时间：2013年7月15日（周一）下午3：00

报告地点：苏州大学神经科学研究所会议室

报告人简介

Personal Information

Name: CHUN GUO

Work address: School of Biochemistry, University of Bristol

Present Appointment

August 2013 – Present Research Fellow (Level c)

School of Biochemistry, University of Bristol, U.K.

August 2009 – July 2013 Research Associate (Level b)

School of Biochemistry, University of Bristol, U.K.

Research Outline

The major aim of his research is to understand basic cell biology and signaling

pathways underlying roles of protein post-translational modifications in cell death, survival and repair

 following stress and injury. He has focused mainly on the mechanisms and consequences of protein SUMOylation.

Publications

1. Guo C, Hildick KL, Luo J, Dearden L, Wilkinson KA, Henley JM. (2013) SENP3-mediated DeSUMOylation of

dynamin-related protein 1 promotes cell death following ischaemia. EMBO J. 32(11):1514-28.

2. Guo C and Whitmarsh AJ. (2008). The β-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3

activation by binding to its non-conserved N-terminus. J. Biol. Chem. 283(23): 15903-11.

3. Guo C, Willem M, Werner A, Raivich G, Emerson M, Neyses L and Mayer U.(2006) Absence of α7 integrin in

dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy. Hum. Mol. Genet. 15(6): 989-98.

4. Guo C*, Jiang J, Elliott JM, and Piacentini L. (2005). Paradigmatic identification of MMP-2 and MT1-MMP

activation systems in cardiac fibroblasts cultured as a monolayer. J. Cell. Biochem. 94(3):446-59.

(*Corresponding author)

5. Guo C* and Piacentini L. (2003). Type I collagen-induced MMP-2 activation coincides with up-regulation of Membrane Type 1-Matrix Metalloproteinase and TIMP-2 in cardiac fibroblasts. J. Biol. Chem. 278 (47):46699-708.

(*Corresponding author)