Name： Yizheng Yao
Teaching Title：Associate Professor
Phone：+86-17772228327
E-mail： yzyao28@suda.edu.cn
Speciality：
1. Biomedical engineering and screening of novel AAV vectors
2. Regulatory Mechanism of neuroinflammation after CNS injury and associated molecular-targeted gene therapy
3. AAV-mediated gene therapy for glioblastoma
Dr.Yao, received B.S. in laboratory medicine and Ph.D in clinical laboratory diagnostics from Jiangsu University in 2013 and 2018 respectively. During his Ph.D period, he conducted his research of doctoral thesis in Harvard Medical School as a joint PhD student. After obtained his PhD degree, he continued to stay in Bei Lab of Brigham and Women’s Hospital at Harvard Medical School as a Postdoctoral Research Fellow until 2022. He devoted into studying AAV vector development and gene therapy for CNS injury in his postdoctoral career. Then he joined Institute of Neuroscience, Soochow University, as a Principal Investigator in Dec. 2022.
His research work has been published in “Nature Biomedical Engineering”, “Nature Protocols”, “Journal of Controlled Release”, etc. He is also a member of Society of Neuroscience and American Society of Gene & Cell Therapy.
Selected Publications：(* first author; # corresponding author )
1. Yao, Y*., Wang, J*., Liu, Y*., Qu, Y*., Wang, K., Zhang, Y., Chang, Y., Yang, Z., Wan, J., Liu, J., Nakashima, H., Lawler, SE., Chiocca, EA., Cho, CF., Bei, F#. (2022). Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates. Nat Biomed Eng 6, 1257-1271. 10.1038/s41551-022-00938-7.
2. Wang, K*., Guo, K*., Ji, Z., Liu, Y., Chen, F., Wu, S., Zhang, Q., Yao, Y#., and Zhou, Q#. (2022). Association of Preeclampsia with Incident Dementia and Alzheimer's Disease among Women in the Framingham Offspring Study. J Prev Alzheimers Dis9, 725-730. 10.14283/jpad.2022.62.
3. Chen, W*., Yao, S*., Wan, J*#., Tian, Y., Huang, L., Wang, S., Akter, F., Wu, Y., Yao, Y#., and Zhang, X#. (2021). BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment. J Control Release 333, 129-138. 10.1016/j.jconrel.2021.03.029.
4. Bhaskaran, V., Yao, Y., Bei, F., and Peruzzi, P#. (2019). Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications. Nat Protoc14, 3538-3553. 10.1038/s41596-019-0241-8.
5. Yao, Y., Shen, Y., Zhu, L., Ni, Y., Wang, H., and Shao, S#. (2018). Preliminary study and bioinformatics analysis on the potential role of CagQ in type IV secretion system of H.pylori. Microb Pathog 116, 1-7.