Name： Cheng jian
TeachingTitle：Professor
Phone： 0512-65884725
E-mail： chengjian@suda.edu.cn
Research Interests：
1）Mechanisms of protection and repair following stroke;
2）Identification of drug targets and development of novel drugs for stroke treatment;
3）Therapeutic mechanisms of hydrogen sulfide in stroke.
Dr. Cheng Jian is a professor and doctoral supervisor at the Institute of Neuroscience of Soochow University. He mainly focuses on the cellular mechanisms of glial cells in injury and repair following stroke, and searches for potential drug targets. From 2009 to 2011, he was an assistant professor in the Department of Anesthesiology, Oregon Health and Technology University. During this period, Dr. Cheng received a grant as a principle investigator from American Heart Association (AHA) regarding stroke research. After returning to China in 2011, Dr. Cheng has received 5 grants from National Natural Science Foundation of China (NSFC), and 1 grant from State Key Laboratory of Pharmaceutical Biotechnology. He has published more than 40 articles in international SCI journals such as Science Advances; held 3 pharmaceutical patents as the first principal inventor; served as a peer reviewer for several SCI journals such as Stroke and Experimental Neurology. In 2017, he won the second prize of Science and Technology Progress Award of the Ministry of Education, and the first prize of Jiangsu Science and Technology Award. Dr. Cheng currently serves as a committee member of Neuroendocrine and Endocrine Sub-professional Committee of Chinese Society of Neuroscience, a committee member of Translational Medicine Branch of Chinese Stroke Association, an executive director of Jiangsu Stroke Association, the chairman of Professional Committee for Basic and Translational Medical Stroke Research of Jiangsu Stroke Association, the vice chairman of Neuroimmunology Branch of Jiangsu Society for Immunology.
Selected Publications：
1、Jia Jia*, Zichuang Wang, Minjie Zhang, Caiyun Huang , Yanmei Song, Fuyou Xu, Jingyu Zhang, Jie Li, Meijun He, Yuyao Li, Guizhen Ao, Chengjiao Hong, Yongjun Cao, Y Eugene Chin, Zi-chun Hua, Jian Cheng*. SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling. Science Advance. 2020; 6 (35): eaaz5752.
2、Xiaoling Yan, Fuyou Xu, Jingjing Ji, Peng Song, Yaqin Pei, Meijun He, Zichuang Wang, Shoujiang You, Zichun Hua, Jian Cheng*, Jia J*. Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage. Acta Pharmacologica Sinica. 2021; 0: 1-18.
3、Jie Li, Jingyu Zhang, Yusuo Zhang, Zichuang Wang, Yanmei Song, Shanwen Wei, Meijun He, Shoujiang You, Jia Jia*, Jian Cheng*. TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis. Cell Death Diseases. 2019, 10(5): 328.
4、Wei Tang, Rong Cheng, Meng-yue Gao, Min-jin Hu, Lu Zhang, Qiang Wang, Xin-yu Li, Wei Yan, Xiao-ying Wang, Hai-mei Yang, Jian Cheng* and Zi-chun Hua*. A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia. Acta Pharmacologica Sinica . 2025 Apr;46(4):852-866.
5、Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia*, Jian Cheng*, Yongjun Cao*. Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke. Advanced Science. 2026 Jan 25:e11482.