Name：Li-Fang Hu
Teaching Title: Professor
Phone: 0512-65884621
E-mail：hulifang@suda.edu.cn
Research Interests:
1) Neuroimmunology andpathogenesis of neurodegenerative diseases (Parkinson's disease) and exploration of drug targets
2) The role of transsulfuration pathway (TSP) in the processes of Parkinson’s disease development.
Resume：
Dr. Li-Fang Hu obtained the PhD degree in the department of Pharmacology in National University of Singapore in 2010. After that, she joined in the Institute of Neuroscience in Soochow University, and was promoted as a PI of Parkinson’s disease (PD) research group in 2015. Her group is interested in understanding the molecular pathogenesis of PD, focusing on the role of microglia-mediated inflammation in the development of PD.Since 2010, she and her team has already published more than 30 articles in peer-reviewed journals including Autophagy, J Neuroinflammation, Aging cellBrain Behavior Immunity, and etc.Now she is a member of the Chinese and American Society for Neuroscience and member of the Chinese Pharmacology society, and serves as the peer reviewer in several SCI journals. As a young PI, she got several grants including the National Natural Science Foundation of China and Jiangsu Province, and the National Key R&D Program of China.She was also elected as ‘high-level creative and innovative talent in Suzhou City’ (2011)and the 16th batch of six talent peaks in Jiangsu Province (2019).
Selected Publications:(* Corresponding author)
1、Liu Y, Wang Z, Ma YT, Chen YX, Qian XY, Hou XO, Wan B, Ren HG,Hu LF*. STAT1 and STAT6 orchestrate Cbs transcription and transsulfur metabolism in microglia and contribute to parkinson's disease-related neuroinflammation.Cell Mol Life Sci. 2025;82:294.(二区)
2、Pei CS, Hou XO, Ma ZY, Tu HY, Qian HC, Li Y, Li K, Liu CF, Ouyang L*, Liu JY*,Hu LF*.α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription.J Neuroinflammation. 2024;21:275. (一区)
3、Mou YJ, Ma YT, Yuan X, Wang M, Liu Y, Pei CS, Liu CF, Hou XO*,Hu LF*.Cystathionine b-Synthase Suppresses NLRP3 Inflammasome Activation via Redox Regulation in Microglia.Antioxid Redox Sign. 2023 Sep 5. (二区)
4、Dong AQ, Yang YP, Jiang SM, Yao XY, Qi D, Mao CJ, Cheng XY, Wang F,Hu LF*, Liu CF*. Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson‘ s disease.Acta Pharmacol Sin.2023; 44(1):32-43. (一区)
5、Tu HY, Yuan BS, Hou XO, Zhang XJ, Pei CS, Ma YT, Yang YP, Fan Y, Qin ZH, Liu CF,Hu LF*. alpha-synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease.Aging Cell. 2021; 20(12): e13522. (一区)
6、Yuan YQ, Wang YL, Yuan BS, Yuan X, Hou XO, Bian JS, Liu CF, Hu LF*. Impaired BS-H2S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson's disease.Brain Behav Immun.2018; 67: 77-90. (二区)
7、Sheng YL, Chen X, Hou XO, Yuan X, Yuan BS, Yuan YQ, Zhang QL, Cao X, Liu CF, Luo WF*,Hu LF*. Urate promotes SNCA/alpha-synuclein clearance via regulating mTOR-dependent macroautophagy.Exp Neurol. 2017; 297: 138-147. (二区)
8、Wang JD, Cao YL, Li Q, Yang YP, Jin MM, Chen D, Wang F, Wang GH, Qin ZH,Hu LF*,Liu CF*. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy.2015;11(11):2057-2073. (一区)