Name：Hong-rui Meng
Teaching Title：Professor
Phone: +86 158*****508
E-mail: hrmeng@suda.edu.cn
Research Interests：
1) Protein misfolding and aggregation in neurodegenerative diseases,
2) Genetic defects and mechanisms of mitochondrial dysfunction in neurodegeneration,
3) Glial biology in neurological disease.
Resume：
Prof. Meng obtained his Ph.D. in Behavioral Neuroscience from Hamamatsu University School of Medicine in Hamamatsu, Japan, in 2013. After completing his postdoctoral training in molecular neurobiology and human genetics at Juntendo University in Tokyo, he joined the faculty as an assistant professor in the Department of Research for Neurodegenerative Diseases and Dementia. He became a full professor in 2020 and established the Laboratory of Molecular Neurology at the Institute of Neuroscience, Soochow University. He is currently the head of the Neurodegenerative Diseases Research Group, dedicated to advancing research on the mechanisms of neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis. His research has been published in prestigious journals like Mol Neurodegener, Nat Commun, PNAS, Cell Commun & Signal, Brain Behav Immun, Commun Bio, PLoS Genet, and Human Mol & Genet.
Selected Related Publications:
1、Miao, Y.; Zhang, T.; Ma, Z.; Du, H.; Gu, Q.; Jiang, M.; Xiong, K.; Liu, C-F.#; Meng, H.R.#. Modulation of O-GlcNAc cycling influences alpha-synuclein amplification, degradation, and associated neuroinflammatory pathology. Mol Neurodegener 2025, 20, 113, doi:10.1186/s13024-025-00904-2.
2、Long, X.; Wang, Y.; Meng, H.R.#. Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency. Curr Issues Mol Biol 2025, 47, doi:10.3390/cimb47060442.
3、Miao, Y.; Meng, H.R.#. The involvement of alpha-synucleinopathy in the disruption of microglial homeostasis contributes to the pathogenesis of Parkinson's disease. Cell Commun Signal 2024, 22, 31, doi:10.1186/s12964-023-01402-y.
4、Sun, Y.; Jiang, M.; Long, X.; Miao, Y.; Du, H.; Zhang, T.; Ma, X.; Zhang, Y.#; Meng, H.R.#. Transcriptomic Analysis of Lipid Metabolism Genes in Alzheimer's Disease: Highlighting Pathological Outcomes and Compartmentalized Immune Status. J Mol Neurosci 2024, 74, 55, doi:10.1007/s12031-024-02225-3.
5、Ikeda, A.*; Meng, H.R.*; Taniguchi, D.; Mio, M.; Funayama, M.; Nishioka, K.; Yoshida, M.; Li, Y.; Yoshino, H.; Inoshita, T.; et al. CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis. PNAS Nexus 2024, 3, pgae319, doi:10.1093/pnasnexus/pgae319.
6、Long, X.; Du, H.; Jiang, M.; Meng, H.R.#. A Simple Technique to Assay Locomotor Activity in Drosophila. J Vis Exp 2023, doi:10.3791/65092.
7、Meng, H.R.; Suenaga, T.; Edamura, M.; Fukuda, A.; Ishida, Y.; Nakahara, D.; Murakami, G. Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression. Brain Behav Immun 2021, 97, 22-31, doi:10.1016/j.bbi.2021.05.015.
8、Imai, Y.; Meng, H.R.; Shiba-Fukushima, K.; Hattori, N. Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Int J Mol Sci 2019, 20, doi:10.3390/ijms20040908.
9、Ikeda, A.; Nishioka, K.; Meng, H.R.; Takanashi, M.; Hasegawa, I.; Inoshita, T.; Shiba-Fukushima, K.; Li, Y.; Yoshino, H.; Mori, A.; et al. Mutations in CHCHD2 cause alpha-synuclein aggregation. Hum Mol Genet 2019, 28, 3895-3911, doi:10.1093/hmg/ddz241.
10、Inoshita, T.; Shiba-Fukushima, K.; Meng, H.R.; Hattori, N.; Imai, Y. Monitoring Mitochondrial Changes by Alteration of the PINK1-Parkin Signaling in Drosophila. Methods Mol Biol 2018, 1759, 47-57, doi:10.1007/7651_2017_9.
11、Meng, H.R.*; Yamashita, C.*; Shiba-Fukushima, K.; Inoshita, T.; Funayama, M.; Sato, S.; Hatta, T.; Natsume, T.; Umitsu, M.; Takagi, J.; et al. Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial cristae structure and destabilizes cytochrome c. Nat Commun 2017, 8, 15500, doi:10.1038/ncomms15500.
12、Inoshita, T.; Arano, T.; Hosaka, Y.; Meng, H.R.; Umezaki, Y.; Kosugi, S.; Morimoto, T.; Koike, M.; Chang, H.Y.; Imai, Y.; et al. Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila. Hum Mol Genet 2017, 26, 2933-2948, doi:10.1093/hmg/ddx179.
13、Imai, Y.; Kobayashi, Y.; Inoshita, T.; Meng, H.R.; Arano, T.; Uemura, K.; Asano, T.; Yoshimi, K.; Zhang, C.L.; Matsumoto, G.; et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet 2015, 11, e1005503, doi:10.1371/journal.pgen.1005503.