Topic: Optogenetic stimulation of striatal glutmatergic activity enhances neurogenesis in the SVZ of normal and stroke mice
Speaker: Prof. Shanping Yu
Report time: March 30(Firday), 2018, 10:00
Report location: Conference room, Institute of Neuroscience, 401-1500
Host：Prof. Guangyin Xu
Brief introduction of the speaker:
Prof. Shanping Yu obtained MD&MS in 1982 in Institute of Pharmacology & Toxicology of Capital Institute of Medicine，Doctor Degree for Physiology in 1990 in State University of New York at Stony Brook, NY. Postdoctoral study for Neuroscience in Howard Hughes Medical Institute in 1992.
His research has focused on the mechanisms of neuronal cell death and neuroprotection/regeneration after hypoxia and ischemia in vitro as well as in animal models. He previous investigations contributed to the identification of novel ionic and molecular mechanisms involving voltage-gated channels and ligand-gated receptors in apoptotic and necrotic cell death. Using electrophysiological and gene modification techniques, we identified specific ion channels, such as Kv2.1 and KCNQ3/4, in mediating apoptotic cell death and neuronal differentiation. Their work revealed novel mechanisms for promoting FAK activation and directional migration of neuronal cells in vitro and in vivo. They are among the first groups in developing the strategy of preconditioning transplanted stem cells and demonstrated the multifaceted pro-survival and pro-regenerative effects of hypoxic preconditioned cells in vitro and after transplantation into the ischemic heart and brain. They have been carrying out the novel optogenetics therapy in stem cell transplantation after ischemic stroke and traumatic brain injury. One of their specialties is the investigation of cognitive and neuropsychological functions using comprehensive approaches, including the recording of LTP in brain slices. Their latest progress is the identification of inflammatory mechanisms that may link early life pain experience to the pathogenesis of autism like syndrome. They have also developed the innovative intranasal delivery of stem cells after stroke and TBI. The non-invasive method targets the CNS for more efficient and more clinically feasible cell delivery. Their current focus is to promote the survival and differentiation of transplanted cells and newly generated endogenous cells for morphological and functional repair of damaged brain structures. Other research in the lab includes direct conversion of glial cells to neurons, drug-induced hypothermia treatments and receptor mechanisms of chronic pain in inflammation and cancer. As a result of my research activities, he has published nearly 150 peer reviewed research papers and reviews/book chapters.
Institute of neuroscience of Soochow University