Xu XingShun
时间: 2022-06-05 作者: 浏览次数: 1
  • Name: Xu XingShun

  • TeachingTitleProfessor, Doctoral Tutor

  • Phone: 0512-65883252

  • E-mail: xingshunxu@hotmail.com

  • Speciality: 1.The mechanisms of brain injury and neuroprotection2.The functions of Ahi1 and the mechanisms of Depression

   Dr. Xingshun Xu graduated from Xuzhou Medical College in July 1996.  After graduation, he worked as a neurologist in the Affiliated Hospital of Xuzhou Medical College.  In May 2003, he went to the USA and received his PhD from East Tennessee State University in December 2007.  He got his postdoctoral training at Emory University from September 2007.  In March 2010, he joined the Institute of Neuroscience at Soochow University.  

   Dr. Xu’s research interests focused on neurological diseases, especially stroke. During his PhD studies, he examined the neuroprotection of different agents on cerebral ischemia injury and explored the mechanisms of cell death including necroptosis, a newly identified programmed cell death. In his postdoctoral training, he explored the function of Ahi1, a Joubert syndrome-related protein. He found that Ahi1 is involved in the regulation of recycling and sorting of TrkB receptor and Ahi1 deficiency causes depression-like phenotype in mice.  His research findings were published in several journals such as PNAs,Stroke,Journal of Neurochemistry, Glia, Human Molecular Genetics and so on. Dr. Xu was appointed Distinguished medical experts, also selected innovation and entrepreneurship program in Jiangsu Province at 2013. In 2015, he got the Science and Technology Progress Award of Jiangsu Province.

 

Selected Publications:

  1. Cheng Y, Sun M, Chen L, Li Y, Lin L, Yao B, Li Z, Wang Z, Chen J, Miao Z, Xin N, Huang L, Allen EG, Wu H, Xu X*, and Jin P*. Ten-eleven translocation proteins modulate the response to environmental stress in mice. Cell reports. 2018 Dec 11; 25:1-10. (1)

  2. Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Sun M*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 1;9(5):520.(2)

  3. Miao Z, He Y, Xin N, Sun M, Chen L, Lin L, Li J, Kong J, Jin P*, Xu X*. Altering 5-hydroxymethylcytosine modification impacts ischemic brain injury. Hum Mol Genet. 2015.24(20):5855-66.(2)

  4. Li X, Zhao H, Tan X, Kostrzewa RM, Du G, Chen Y, Zhu J, Miao Z, Yu H, Kong J, Xu X*. Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats. Glia. 2015 Sep;63(9):1553-67.(2)

  5. Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. PNAS. 107(44):19126-31.(1)