Wellcome  Institute of Neuroscience, Soochow University ID:游客 [登陆]


来源:本站作者:刘晓红发布于:2015-06-22 人阅读

Topic:Laterodorsal tegmentum bidirectionally controls predator odor induced innate fear through two interneuron subtypes


Reporter:WangHao, Ph.D. Institute of Neuroscience,Zhejiang University


Time:2015.6.23 10:00AM


Location: Meeting Room, Institute of Neuroscience, Soochow University


Introduction of reporter:


Neural circuitry for innate fear


Innate fear is a kind of inherited fear of specific objects, environment or situation without learning. For example, rodents are fear of cats by nature. Even native mice will express fear response in the present of a cat. This emotion trigged by a perceived threat usually causes a quick response, such as freezing, flee or hide, and thus has a profound role for survival and health for all species. Abnormal innate fear in humans particularly phobias and panic disorders is highly associated with anxiety disorder. Recent studies suggested that innate fear induced by different cues were attributed by distinctive neural circuits. Vision and auditory cues, but not olfactory cue induced innate fear is related amygdala. So far, which parts of the brain are involved in olfactory cue induced innate fear remains unclear. We will combine electrophysiological, immunohistochemical, optogenetics and animal behavioral assays to explore the neural circuit for odor induced innate fear.


Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan S, Yu YQ. 2014. Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. CurrBiol, 24(6):693-698


Li HQ, Chen C, Dou Y, Wu HJ, Liu YJ, Lou HF, Zhang JM, Li XM, Wang H, Duan S. 2013. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Bio, 33(21):4282-4293


Wang H, Liu H, Zhang ZW.  2011. Elimination of redundant synaptic inputs in the absence of synaptic strengthening. J Neurosci 31(46):16675-16684.


Wang H, Liu H, Storm D, Zhang ZW. 2011. Adenylate cyclase 1 promotes strengthening and experience-dependent plasticity of whisker relay synapses in the thalamus. J Physiol, 589:5649-5662.