Wellcome  Institute of Neuroscience, Soochow University ID:游客 [登陆]

SEMINARA(97)

来源:本站作者:刘晓红发布于:2015-04-07 人阅读

Topic:Mitochondrial dynamic abnormalities in Alzheimer’s Disease

 

 
 

Reporter:Xinglong Wang, Ph.D.

 

Time:2015.4.2910:00AM

 

Location: Meeting Room, Institute of Neuroscience, Soochow University

 

Introduction of reporter:

PRIMARY APPOINTMENTS:

2011-2013 Instructor, Department of Pathology & Neurology, Case Western Reserve University, Cleveland, Ohio, USA

2013- Assistant Professor (tenure track), Department of Pathology & Neurology, Case Western Reserve University, Cleveland, Ohio, USA

Research

DoctorWang’s research interest is to understand the mechanism(s) underlying neuronal death in neurodegenerative diseases. The major focus of his current work is the mechanisms underlying mitochondrial dysfunction in Amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD). Mitochondrial dysfunction has long been recognized as a prominent feature of ALS, AD and PD. However, the mechanisms responsible for the mitochondrial impairment, and its role in these diseases were not clear. Recent studies in the field of basic research on mitochondria reveal that they are dynamic organelles that undergo continual fission and fusion events which serve crucial physiological function. Riding on this recent tide of extensive characterization of mitochondrial dynamics, studies are underway to investigate the role of mitochondria dynamics in the pathogenesis of ALS, AD and PD. Specific questions include: Whether and how disease-associated genetic factors affects mitochondrial dynamics and function; whether and how alterations in mitochondrial dynamics cause disease-relevant changes; How we target mitochondrial dynamics for therapeutic development?