Wellcome  Institute of Neuroscience, Soochow University ID:游客 [登陆]

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来源:本站作者:刘安琪发布于:2017-08-29 人阅读

Report Title: Tubular ER in Alzheimer’s pathogenesis

Reporter: Prof. Riqiang Yan

Report time: September 8, 2017, 10:00am

Location: Meeting Room, Institute of Neuroscience, Soochow  University

 

Introduction:

Riqiang Yan, professor. In 1993, he was graduated from the University of Kentucky with a Ph.D. And then he had a postdoctoral research in biochemistry at Rockefeller University in the United States. Currently, he is the professor of Cleveland Clinic Lerner College of Medicine at CMRU; Vice Chair of Dept. of Neuroscience, Lerner Research Institute, Morris R and Ruth V. Graham Endowed Chair of Cleveland Clinic. In addition, Prof. Yan is a member of the National Scientific Advisory Council, the American Federation for Aging Research, a Scientific Review Committee and the American Health Assistance Foundation. He is also a reviewer of Welcome Foundation (UK), Alzheimer’s Society (UK), the executive editor of the International Journal of Clinical and Experimental Pathology, senior editor of the American Journal of Translational Research and many other honors and duties.

 

Prof. Yan is mainly engaged in the study of the pathogenesis of Alzheimer's disease. He discovered BACE1. His lab has been of one the first to demonstrate how BACE1 and BACE2 differentially cleave APP. After these original discoveries, they have focused major studies on biological functions of BACE1 in vivo, and found that neuregulin-1, neuregulin-3, Jag1 and Jag2 are BACE1 physiological substrates. Their work has been published in Nature, Nature Medicine, Nature Neuroscience, Molecular Psychiatry, Cell Report, EMBO J, Biological Psychiatry, Journal of Neuroscience and other journals.