报告题目：Direct Visualization of Single molecule Amyloid Beta peptides in Action by High-Speed AFM
报告人：冯磊 (Lei Feng) 研究员
单位：蒙纳士苏州 (Monash Suzhou)
Lei Feng is currently a Research Fellow with Monash Suzhou Research Institute, China, and a Research Coordinator with center of Life (Medical/Bio) Science Monash University, Australia. Prior to that, he was a Postdoctoral Research Associate at the Australian Institute of Innovative Materials, Australia. In 2019, Lei Feng received his Ph.D. degree in Biochemistry from the University of Wollongong, Australia. His research interests include Single molecule dynamics, Nanomaterial-protein interactions, and Alzheimer’s.
Within the amyloid hypothesis in Alzheimer’s disease, current focus has shifted to earlier stage of amyloid beta (Aβ) peptide assembly, involving insoluble oligomers and small aggregates that are more toxic to cells compared to their morphological distinct fibril forms. Critical to the Aβ field is unlocking the molecular level kinetic pathways or mechanisms of oligomerization, leading to culprit subset or specific species of Aβ oligomer populations responsible for the disease etiology. Herein, we employ High-Speed AFM to directly “watching” and reveal single molecule dynamics at sub-molecular spatial resolution.